This website uses cookies to store information on your computer. Some of these cookies are used for visitor analysis, others are essential to making our site function properly and improve the user experience. By using this site, you consent to the placement of these cookies. Click Accept to consent and dismiss this message or Deny to leave this website. Read our Privacy Statement for more.
ISPAD Guidelines 2018 -Chapter 3:The Diagnosis and management of monogenic diabetes in children

Chapter 4: The Diagnosis and management of monogenic diabetes in Children

 Andrew T. Hattersley, Siri Atma W Greeley, Michel Polak, Oscar Rubio-Cabezas, Pål R Njølstad, Wojciech Mlynarski, Luis Castano, Annelie Carlsson, Klemens Raile, Dung Vu Chi, Sian Ellard, Maria E Craig 

Chapter Highlights:

  • The presentation of a familial form of diabetes in young people should raise the suspicion of monogenic diabetes, with recent data indicating that approx. 1–6% of pediatric diabetes cases have monogenic diabetes
  • Next-generation sequencing (NGS) enables the simultaneous analysis of multiple genes at a lower cost and has already become a feasible alternative to traditional genetic testing in cases of suspected monogenic diabetes
  • All patients diagnosed with diabetes in the first 6 months of life should have immediate molecular genetic testing to define their subtype of monogenic neonatal diabetes mellitus
  • Based on key gene variants associated with type 1 diabetes, composite type 1 diabetes genetic risk scores provide a novel tool to differentiate type 1 diabetes from monogenic and type 2 diabetes. 
  • The differentiation between type 1, type 2, monogenic and other forms of diabetes has important implications for both therapeutic decisions and educational approaches.

Contact Us

ISPAD Executive Office
c/o K.I.T. Group GmbH
Association & Conference Management
Kurfürstendamm 71
10709 Berlin, Germany










Join ISPAD

Click the link below to join the Society!


Join Today!










Phone: +49 (0)30 24603-210
Fax: +49 (0)30 24603-200
Email: secretariat@ispad.or
g










Privacy Policy
Terms of Service
Legal Notice    

Disclaimer



































 © 2018 International Society for Pediatric and Adolescent Diabetes (ISPAD)






Association Management Software Powered by YourMembership  ::  Legal